Shen lab research interest:

We are mainly interested in understanding the regulation mechanism of central nervous circuit construction and behavioral output.

1. Regulation mechanism of proliferation and differentiation of neural progenitor cells.

We mainly study the regulation mechanism of radial glial cells in the process of proliferation and differentiation of nerve cells; explains the construction mechanism of neural circuits; the basic principle of integrating differentiated cells into neural circuits; screens the nascent proteins involved in visual experience dependence; The impact and mechanism of structure and function on behavioral output.

2. The relationship between neural circuit balance and neurological diseases.

The Balance of Excitation to Inhibition plays an important role in regulating the function and construction of the neural circuit, and is also closely related to autism, epilepsy and schizophrenia. By changing the excitation or inhibition of neurons, we study proteins and signaling molecules related to neural circuit function and behavioral plasticity, which provide a theoretical basis for the treatment of neurological diseases and the design of new drugs.